1377 Exploring the factors to regulate sweating by transcriptome analysis for anhidrosis: Novel role of olfactory receptors on sweating via exposing to β-ionone

Sweat maintains systemic homeostasis in humans. mainly includes certain metabolites, antibiotic peptides, and electrolytes. contribute to the regulation of body temperature, immune defense, moisture retention. Acquired idiopathic generalized anhidrosis (AIGA) is an intractable disease, that cause fatal heatstroke skin dryness. Although symptoms related AIGA apparently impairs patients’ QOLs, there are few promising treatment strategies for AIGA. The etiology remains obscure, therapy disease not established. Thus, investigation study underlying urgent task. To clarify pathogenesis AIGA, transcriptome analysis was employed find pathogenic genes by comparing specimen between anhidrotic hidrotic area patients. Unexpectedly, expression olfactory receptor up-regulated sweat glands, were down-regulated glands. We then confirmed OR51A7 OR51E2 human eccrine glands situ hybridization immunohistochemistry. An alkaline phosphatase-transforming growth factor α shedding assay revealed β-ionone activates G proteins through or OR51E2. effect topically applied on sweating examined with quantitative sudomotor axon reflex test, which showed responses differed genders. Results vitro vivo experiments indicated possibility regulating activity via receptors.